Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting

The hu14.18-IL2 (EMD 273063) IC, consisting of a GD(2)-specific mAb genetically engineered to two molecules of IL-2, is in clinical trials for treatment of GD(2)-expressing tumors. Anti-tumor activity of IC in vivo and in vitro involves NK cells. We studied the kinetics of retention of IC on the sur...

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Detalhes bibliográficos
Main Authors: Buhtoiarov, Ilia N., Neal, Zane C., Gan, Jacek, Buhtoiarova, Tatiana N., Patankar, Manish S., Gubbels, Jennifer A. A., Hank, Jacquelyn A., Yamane, Brett, Rakhmilevich, Alexander L., Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2011
Assuntos:
Translational & Clinical Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058817/
https://ncbi.nlm.nih.gov/pubmed/21248148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0710422
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