Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting

The hu14.18-IL2 (EMD 273063) IC, consisting of a GD(2)-specific mAb genetically engineered to two molecules of IL-2, is in clinical trials for treatment of GD(2)-expressing tumors. Anti-tumor activity of IC in vivo and in vitro involves NK cells. We studied the kinetics of retention of IC on the sur...

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Главные авторы: Buhtoiarov, Ilia N., Neal, Zane C., Gan, Jacek, Buhtoiarova, Tatiana N., Patankar, Manish S., Gubbels, Jennifer A. A., Hank, Jacquelyn A., Yamane, Brett, Rakhmilevich, Alexander L., Reisfeld, Ralph A., Gillies, Stephen D., Sondel, Paul M.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Leukocyte Biology 2011
Предметы:
Translational & Clinical Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058817/
https://ncbi.nlm.nih.gov/pubmed/21248148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0710422
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