Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction

The induction of tumor-protective immunity against malignancies remains a major challenge in cancer immunotherapy. A novel, humanized anti-ganglioside-GD(2)–IL-2 immunocytokine (hu14.18–IL-2) induced CD8(+) T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a proces...

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Hlavní autoři: Lode, Holger N., Xiang, Rong, Pertl, Ursula, Förster, Elisabeth, Schoenberger, Stephen P., Gillies, Stephen D., Reisfeld, Ralph A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC300854/
https://ncbi.nlm.nih.gov/pubmed/10841521
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