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Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia
Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human–mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755890/ https://ncbi.nlm.nih.gov/pubmed/20171010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2010.01.024 |
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