Streptavidin in Antibody Pretargeting. 5. Chemical Modification of Recombinant Streptavidin for Labeling with the α-Particle Emitting Radionuclides (213)Bi and (211)At

Por Wilbur, D. Scott, Hamlin, Donald K., Chyan, Ming-Kuan, Brechbiel, Martin W.
Publicado em 2007

Reagents for Astatination of Biomolecules. 3. Comparison of closo-Decaborate(2-) and closo-Dodecaborate(2-) Moieties as Reactive Groups for Labeling with Astatine-211

Por Wilbur, D. Scott, Chyan, Ming-Kuan, Hamlin, Donald K., Perry, Matthew A.
Publicado em 2009

Preparation and In Vivo Evaluation of Radioiodinated closo-Decaborate(2-) Derivatives to Identify Structural Components That Provide Low Retention in Tissues

Por Wilbur, D. Scott, Chyan, Ming-Kuan, Hamlin, Donald K., Perry, Matthew A.
Publicado em 2010

Reagents for Astatination of Biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab′ as a means of decreasing kidney...

Por Wilbur, D. Scott, Chyan, Ming-Kuan, Hamlin, Donald K., Nguyen, Holly, Vessella, Robert L.
Publicado em 2011

Pilot Study of a (213)Bismuth-labeled anti-CD45 MAb as a Novel Nonmyeloablative Conditioning for DLA-Haploidentical Littermate Hematopoietic Transplantation

Por Nakamae, Hirohisa, Kerbauy, Fabio R, Wilbur, D. Scott, Bethge, Wolfgang, Hamlin, Donald K., Santos, Erlinda B., Storb, Rainer, Sandmaier, Brenda M.
Publicado em 2010

Reagents for astatination of biomolecules. 6. An intact antibody conjugated with a maleimido-closo-decaborate(2-) reagent via sulfhydryl groups had considerably higher kidney conce...

Por Wilbur, D. Scott, Chyan, Ming-Kuan, Nakamae, Hirohisa, Chen, Yun, Hamlin, Donald K., Santos, Erlinda B., Kornblit, Brian T., Sandmaier, Brenda M.
Publicado em 2012

Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211–labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation

Por Chen, Yun, Kornblit, Brian, Hamlin, Donald K., Sale, George E., Santos, Erlinda B., Wilbur, D. Scott, Storer, Barry E., Storb, Rainer, Sandmaier, Brenda M.
Publicado em 2012

Reagents for Astatination of Biomolecules. 4. Comparison of Maleimido-closo-Decaborate(2-) and meta-[(211)At]Astatobenzoate Conjugates for Labeling anti-CD45 Antibodies with [(211)...

Por Wilbur, D. Scott, Thakar, Monica S., Hamlin, Donald K., Santos, Erlinda B., Chyan, Ming-Kuan, Nakamae, Hirohisa, Pagel, John M., Press, Oliver W., Sandmaier, Brenda M.
Publicado em 2009

(211)Astatine-Conjugated Monoclonal CD45 Antibody-Based Nonmyeloablative Conditioning for Stem Cell Gene Therapy

Por Burtner, Christopher R., Chandrasekaran, Devikha, Santos, Erlinda B., Beard, Brian C., Adair, Jennifer E., Hamlin, Donald K., Wilbur, D. Scott, Sandmaier, Brenda M., Kiem, Hans-Peter
Publicado no Hum Gene Ther (2015)

A comparative analysis of conventional and pretargeted radioimmunotherapy of B-cell lymphomas by targeting CD20, CD22, and HLA-DR singly and in combinations

Por Pagel, John M., Orgun, Nural, Hamlin, Donald K., Wilbur, D. Scott, Gooley, Theodore A., Gopal, Ajay K., Park, Steven I., Green, Damian J., Lin, Yukang, Press, Oliver W.
Publicado em 2009

Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas

Por Pantelias, Anastasia, Pagel, John M., Hedin, Nathan, Saganic, Laura, Wilbur, Shani, Hamlin, Donald K., Wilbur, D. Scott, Lin, Yukang, Stone, Diane, Axworthy, Don, Gopal, Ajay K., Press, Oliver W.
Publicado em 2007

Pretargeted Radioimmunotherapy Using Anti-CD45 Monoclonal Antibodies to Deliver Radiation to Murine Hematolymphoid Tissues and Human Myeloid Leukemia

Por Pagel, John M., Matthews, Dana C., Kenoyer, Aimee, Hamlin, Donald K., Wilbur, Daniel S., Fisher, Darrell R., Gopal, Ajay K., Lin, Yukang, Saganic, Laura, Appelbaum, Frederick R., Press, Oliver W.
Publicado em 2009

Biodistributions, Myelosuppression and Toxicities in Mice Treated with an Anti-CD45 Antibody Labeled with the α-Emitting Radionuclides Bismuth-213 or Astatine-211

Por Nakamae, Hirohisa, Wilbur, D. Scott, Hamlin, Donald K., Thakar, Monica S., Santos, Erlinda B., Fisher, Darrell R., Kenoyer, Aimee L., Pagel, John M., Press, Oliver W., Storb, Rainer, Sandmaier, Brenda M.
Publicado em 2009

Eradication of disseminated leukemia in a syngeneic murine leukemia model using pretargeted anti-CD45 radioimmunotherapy

Por Pagel, John M., Hedin, Nathan, Drouet, Lacey, Wood, Brent L., Pantelias, Anastasia, Lin, Yukang, Hamlin, Donald K., Wilbur, D. Scott, Gopal, Ajay K., Green, Damian, Appelbaum, Frederick R., Press, Oliver W.
Publicado em 2008

Design and Synthesis of Bis-Biotin-Containing Reagents for Applications Utilizing Monoclonal Antibody-Based Pretargeting Systems with Streptavidin Mutants

Por Wilbur, D. Scott, Park, Steven I., Chyan, Ming-Kuan, Wan, Feng, Hamlin, Donald K., Shenoi, Jaideep, Lin, Yukang, Wilbur, Shani M., Buchegger, Franz, Pantelias, Anastasia, Pagel, John M., Press, Oliver W.
Publicado em 2010

Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates

Por Green, Damian J., Pagel, John M., Nemecek, Eneida R., Lin, Yukang, Kenoyer, Aimee, Pantelias, Anastasia, Hamlin, Donald K., Wilbur, D. Scott, Fisher, Darrell R., Rajendran, Joseph G., Gopal, Ajay K., Park, Steven I., Press, Oliver W.
Publicado em 2009

Anti-CD45 radioimmunotherapy using (211)At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

Por Orozco, Johnnie J., Bäck, Tom, Kenoyer, Aimee, Balkin, Ethan R., Hamlin, Donald K., Wilbur, D. Scott, Fisher, Darrell R., Frayo, Shani L., Hylarides, Mark D., Green, Damian J., Gopal, Ajay K., Press, Oliver W., Pagel, John M.
Publicado em 2013

Anti-CD45 Radioimmunotherapy with (90)Y but Not (177)Lu Is Effective Treatment in a Syngeneic Murine Leukemia Model

Por Orozco, Johnnie J., Balkin, Ethan R., Gooley, Ted A., Kenoyer, Aimee, Hamlin, Donald K., Wilbur, D. Scott, Fisher, Darrell R., Hylarides, Mark D., Shadman, Mazyar, Green, Damian J., Gopal, Ajay K., Press, Oliver W., Pagel, John M.
Publicado no PLoS One (2014)

Alpha imaging confirmed efficient targeting of CD45-positive cells after astatine-211 ((211)At)-radioimmunotherapy for hematopoietic cell transplantation

Por Frost, Sofia H.L., Miller, Brian W., Bäck, Tom A., Santos, Erlinda B., Hamlin, Donald K., Knoblaugh, Sue E., Frayo, Shani L., Kenoyer, Aimee L., Storb, Rainer, Press, Oliver W., Wilbur, D. Scott, Pagel, John M., Sandmaier, Brenda M.
Publicado no J Nucl Med (2015)

Pretargeted Radioimmunotherapy using Genetically Engineered Antibody-Streptavidin Fusion Proteins for Treatment of Non-Hodgkin Lymphoma

Por Park, Steven I., Shenoi, Jaideep, Frayo, Shani M., Hamlin, Donald K., Lin, Yukang, Wilbur, D. Scott, Stayton, Patrick S., Orgun, Nural, Hylarides, Mark, Buchegger, Franz, Kenoyer, Aimee L., Axtman, Amanda, Gopal, Ajay K., Green, Damian J., Pagel, John M., Press, Oliver W.
Publicado em 2011