Pretargeted Radioimmunotherapy Using Anti-CD45 Monoclonal Antibodies to Deliver Radiation to Murine Hematolymphoid Tissues and Human Myeloid Leukemia

Radioimmunotherapy (RIT) for treatment of hematological malignancies frequently fails because of disease recurrence. We therefore conducted pretargeted (P)RIT studies to augment the efficacy in mice of therapy using a pretargeted anti-human (h)CD45 antibody (Ab)-streptavidin (SA) conjugate followed...

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Detalhes bibliográficos
Main Authors: Pagel, John M., Matthews, Dana C., Kenoyer, Aimee, Hamlin, Donald K., Wilbur, Daniel S., Fisher, Darrell R., Gopal, Ajay K., Lin, Yukang, Saganic, Laura, Appelbaum, Frederick R., Press, Oliver W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613544/
https://ncbi.nlm.nih.gov/pubmed/19118002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2513
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