Design and Synthesis of Bis-Biotin-Containing Reagents for Applications Utilizing Monoclonal Antibody-Based Pretargeting Systems with Streptavidin Mutants

Previous studies have shown that pretargeting protocols, using cancer-targeting fusion proteins, composed of 4 anti-CD20 single chain Fv (scFv) fragments and streptavidin (scFv(4)-SAv), followed by a biotinylated dendrimeric N-acetyl-galactosamine blood clearing agent (CA), 1, then a radiolabeled DO...

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Detalhes bibliográficos
Main Authors: Wilbur, D. Scott, Park, Steven I., Chyan, Ming-Kuan, Wan, Feng, Hamlin, Donald K., Shenoi, Jaideep, Lin, Yukang, Wilbur, Shani M., Buchegger, Franz, Pantelias, Anastasia, Pagel, John M., Press, Oliver W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912428/
https://ncbi.nlm.nih.gov/pubmed/20597486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100030q
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