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Preparation and In Vivo Evaluation of Radioiodinated closo-Decaborate(2-) Derivatives to Identify Structural Components That Provide Low Retention in Tissues

INTRODUCTION: In vivo deastatination of (211)At-labeled biomolecules can severely limit their use in endoradiotherapy. Our studies have shown that the use of closo-decaborate(2-) moiety for (211)At-labeling of biomolecules provides high in vivo stability towards deastatination. However, data from th...

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Main Authors: Wilbur, D. Scott, Chyan, Ming-Kuan, Hamlin, Donald K., Perry, Matthew A.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822733/
https://ncbi.nlm.nih.gov/pubmed/20152716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2009.10.004
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