Deficits in Adult Neurogenesis, Contextual Fear Conditioning, and Spatial Learning in a Gfap Mutant Mouse Model of Alexander Disease

by Hagemann, Tracy L., Paylor, Richard, Messing, Albee
Published 2013

Genetic Ablation of Nrf2/Antioxidant Response Pathway in Alexander Disease Mice Reduces Hippocampal Gliosis but Does Not Impact Survival

by Hagemann, Tracy L., Jobe, Emily M., Messing, Albee
Published 2012

GFAP expression as an indicator of disease severity in mouse models of Alexander disease

by Jany, Paige L., Hagemann, Tracy L., Messing, Albee
Published 2013

Alexander Disease-Associated Glial Fibrillary Acidic Protein Mutations in Mice Induce Rosenthal Fiber Formation and a White Matter Stress Response

by Hagemann, Tracy L., Connor, Jolien X., Messing, Albee
Published in J Neurosci (2006)

Strategies for treatment in Alexander disease

by Messing, Albee, Daniels, Christine M. LaPash, Hagemann, Tracy L.
Published 2010

An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease

by Wang, Liqun, Hagemann, Tracy L., Messing, Albee, Feany, Mel B.
Published in J Neurosci (2016)

Suppression of GFAP toxicity by αB-crystallin in mouse models of Alexander disease

by Hagemann, Tracy L., Boelens, Wilbert C., Wawrousek, Eric F., Messing, Albee
Published 2009

The effect of glial fibrillary acidic protein expression on neurite outgrowth from retinal explants in a permissive environment

by Toops, Kimberly A, Hagemann, Tracy L, Messing, Albee, Nickells, Robert W
Published 2012

Dual transgenic reporter mice as a tool for monitoring expression of GFAP

by Cho, Woosung, Hagemann, Tracy L., Johnson, Delinda A., Johnson, Jeffrey A., Messing, Albee
Published 2009

Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

by Chen, Mei-Hsuan, Hagemann, Tracy L., Quinlan, Roy A., Messing, Albee, Perng, Ming-Der
Published 2013

Nitric oxide mediates glial-induced neurodegeneration in Alexander disease

by Wang, Liqun, Hagemann, Tracy L., Kalwa, Hermann, Michel, Thomas, Messing, Albee, Feany, Mel B.
Published in Nat Commun (2015)

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phen...

by Boyd, Michelle M., Litscher, Suzanne J., Seitz, Laura L., Messing, Albee, Hagemann, Tracy L., Collier, Lara S.
Published in J Neuroinflammation (2021)

Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease

by Hagemann, Tracy L., Powers, Berit, Mazur, Curt, Kim, Aneeza, Wheeler, Steven, Hung, Gene, Swayze, Eric, Messing, Albee
Published in Ann Neurol (2018)

Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

by Tian, Rujin, Wu, Xiaoping, Hagemann, Tracy L., Sosunov, Alexandre A., Messing, Albee, McKhann, Guy M., Goldman, James E.
Published 2010

Beneficial Effects of Nrf2 Overexpression in a Mouse Model of Alexander Disease

by LaPash Daniels, Christine M., Austin, Elizabeth V., Rockney, Danica E., Jacka, Elizabeth M., Hagemann, Tracy L., Johnson, Delinda A., Johnson, Jeffrey A., Messing, Albee
Published 2012

Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease

by Wang, Liqun, Xia, Jing, Li, Jonathan, Hagemann, Tracy L., Jones, Jeffrey R., Fraenkel, Ernest, Weitz, David A., Zhang, Su-Chun, Messing, Albee, Feany, Mel B.
Published in Nat Commun (2018)

Type II Alexander disease caused by splicing errors and aberrant overexpression of an uncharacterized GFAP isoform.

by Helman, Guy, Takanohashi, Asako, Hagemann, Tracy L., Perng, Ming D., Walkiewicz, Marzena, Woidill, Sarah, Sase, Sunetra, Cross, Zachary, Du, Yangzhu, Zhao, Ling, Waldman, Amy, Haake, Bret C., Fatemi, Ali, Brenner, Michael, Sherbini, Omar, Messing, Albee, Vanderver, Adeline, Simons, Cas
Published in Hum Mutat (2020)