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Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

Alexander disease (AxD) is a leukodystrophy caused by heterozygous mutations in the gene for glial fibrillary acidic protein, an intermediate filament protein expressed by astrocytes. The mutation causes prominent protein aggregates inside astrocytes; there is also loss of myelin and oligodendrocyte...

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Detalhes bibliográficos
Main Authors: Tian, Rujin, Wu, Xiaoping, Hagemann, Tracy L., Sosunov, Alexandre A., Messing, Albee, McKhann, Guy M., Goldman, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342699/
https://ncbi.nlm.nih.gov/pubmed/20448479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181d3cb52
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