Phenotypic Conversions of “Protoplasmic” to “Reactive” Astrocytes in Alexander Disease

Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). Astrocytes in AxD display hypertrophy, massive increases in GFAP, and the accumulation of Ro...

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Main Authors: Sosunov, Alexander A., Guilfoyle, Eileen, Wu, Xiaoping, McKhann, Guy M., Goldman, James E.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694721/
https://ncbi.nlm.nih.gov/pubmed/23616550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4506-12.2013
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