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Phenotypic Conversions of “Protoplasmic” to “Reactive” Astrocytes in Alexander Disease

Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). Astrocytes in AxD display hypertrophy, massive increases in GFAP, and the accumulation of Ro...

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Détails bibliographiques
Auteurs principaux: Sosunov, Alexander A., Guilfoyle, Eileen, Wu, Xiaoping, McKhann, Guy M., Goldman, James E.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694721/
https://ncbi.nlm.nih.gov/pubmed/23616550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4506-12.2013
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