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Phenotypic Conversions of “Protoplasmic” to “Reactive” Astrocytes in Alexander Disease
Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). Astrocytes in AxD display hypertrophy, massive increases in GFAP, and the accumulation of Ro...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694721/ https://ncbi.nlm.nih.gov/pubmed/23616550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4506-12.2013 |
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