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Alexander disease: an astrocytopathy that produces a leukodystrophy

Alexander Disease (AxD) is a degenerative disorder caused by mutations in the GFAP gene, which encodes the major intermediate filament of astrocytes. As other cells in the CNS do not express GFAP, AxD is a primary astrocyte disease. Astrocytes acquire a large number of pathological features, includi...

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Detalhes bibliográficos
Publicado no:Brain Pathol
Main Authors: Sosunov, Alexander, Olabarria, Markel, Goldman, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028392/
https://ncbi.nlm.nih.gov/pubmed/29740945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12601
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