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Alexander Disease-Associated Glial Fibrillary Acidic Protein Mutations in Mice Induce Rosenthal Fiber Formation and a White Matter Stress Response

Mutations in the gene for the astrocyte specific intermediate filament, glial fibrillary acidic protein (GFAP), cause the rare leukodystrophy Alexander disease (AxD). To study the pathology of this primary astrocyte defect, we have generated knock-in mice with missense mutations homologous to those...

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Bibliografische gegevens
Gepubliceerd in:J Neurosci
Hoofdauteurs: Hagemann, Tracy L., Connor, Jolien X., Messing, Albee
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674663/
https://ncbi.nlm.nih.gov/pubmed/17065456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3260-06.2006
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