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Alexander Disease-Associated Glial Fibrillary Acidic Protein Mutations in Mice Induce Rosenthal Fiber Formation and a White Matter Stress Response

Mutations in the gene for the astrocyte specific intermediate filament, glial fibrillary acidic protein (GFAP), cause the rare leukodystrophy Alexander disease (AxD). To study the pathology of this primary astrocyte defect, we have generated knock-in mice with missense mutations homologous to those...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Hagemann, Tracy L., Connor, Jolien X., Messing, Albee
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674663/
https://ncbi.nlm.nih.gov/pubmed/17065456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3260-06.2006
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