Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

IF (intermediate filament) proteins can be cleaved by caspases to generate proapoptotic fragments as shown for desmin. These fragments can also cause filament aggregation. The hypothesis is that disease-causing mutations in IF proteins and their subsequent characteristic histopathological aggregates...

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Detalhes bibliográficos
Main Authors: Chen, Mei-Hsuan, Hagemann, Tracy L., Quinlan, Roy A., Messing, Albee, Perng, Ming-Der
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Neurochemistry 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833455/
https://ncbi.nlm.nih.gov/pubmed/24102621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20130032
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