Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

IF (intermediate filament) proteins can be cleaved by caspases to generate proapoptotic fragments as shown for desmin. These fragments can also cause filament aggregation. The hypothesis is that disease-causing mutations in IF proteins and their subsequent characteristic histopathological aggregates...

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Bibliographic Details
Main Authors: Chen, Mei-Hsuan, Hagemann, Tracy L., Quinlan, Roy A., Messing, Albee, Perng, Ming-Der
Format: Artigo
Language:Inglês
Published: American Society for Neurochemistry 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833455/
https://ncbi.nlm.nih.gov/pubmed/24102621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20130032
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