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The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP

Alexander disease (AxD) is a primary genetic disorder of astrocytes caused by dominant mutations in the gene encoding the intermediate filament (IF) protein GFAP. This disease is characterized by excessive accumulation of GFAP, known as Rosenthal fibers, within astrocytes. Abnormal GFAP aggregation...

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Foilsithe in:Mol Biol Cell
Main Authors: Lin, Ni-Hsuan, Huang, Yu-Shan, Opal, Puneet, Goldman, Robert D., Messing, Albee, Perng, Ming-Der
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Cell Biology 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156539/
https://ncbi.nlm.nih.gov/pubmed/27798231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-06-0362
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