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An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease

The role that glia play in neurological disease is poorly understood but increasingly acknowledged to be critical in a diverse group of disorders. Here we use a simple genetic model of Alexander disease, a progressive and severe human degenerative nervous system disease caused by a primary astroglia...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Wang, Liqun, Hagemann, Tracy L., Messing, Albee, Feany, Mel B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737762/
https://ncbi.nlm.nih.gov/pubmed/26843629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0256-15.2016
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