GFAP expression as an indicator of disease severity in mouse models of Alexander disease

AxD (Alexander disease) is a rare disorder caused by heterozygous mutations in GFAP (glial fibrillary acidic protein) resulting in accumulation of the GFAP protein and elevation of Gfap mRNA. To test whether GFAP itself can serve as a biomarker of disease status or progression, we investigated two i...

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Hlavní autoři: Jany, Paige L., Hagemann, Tracy L., Messing, Albee
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Neurochemistry 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604736/
https://ncbi.nlm.nih.gov/pubmed/23432455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20130003
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