Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death

by Mohideen, Firaz, Paulo, Joao A., Ordureau, Alban, Gygi, Steve P., Harper, J. Wade
Published in Mol Cell Proteomics (2017)

Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly

by Lucena, Rafael, Dephoure, Noah, Gygi, Steve P., Kellogg, Douglas R., Tallada, Victor A., Daga, Rafael R., Jimenez, Juan
Published in J Cell Biol (2015)

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation

by Zeng, Xing, Jedrychowski, Mark P., Chen, Yi, Serag, Sara, Lavery, Gareth G., Gygi, Steve P., Spiegelman, Bruce M.
Published in Genes Dev (2016)

Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells

by Soustek, Meghan S., Balsa, Eduardo, Barrow, Joeva J., Jedrychowski, Mark, Vogel, Rutger, Jan Smeitink, Gygi, Steve P., Puigserver, Pere
Published in Cell Death Dis (2018)

Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma

by Zhou, Shuang, Appleman, Vicky A, Rose, Christopher M, Jun, Hyun Jung, Yang, Juechen, Zhou, Yue, Bronson, Roderick T, Gygi, Steve P, Charest, Al
Published in Life Sci Alliance (2018)

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes Through PERK/eIF2α Axis

by Balsa, Eduardo, Soustek, Meghan S., Thomas, Ajith, Cogliati, Sara, García-Poyatos, Carolina, Martín-García, Elena, Jedrychowski, Mark, Gygi, Steve P., Enriquez, José Antonio, Puigserver, Pere
Published in Mol Cell (2019)

Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity

by Gyuris, Aron, Navarrete-Perea, Jose, Jo, Ala, Cristea, Simona, Zhou, Shuang, Fraser, Kyle, Wei, Zhiyun, Krichevsky, Anna M., Weissleder, Ralph, Lee, Hakho, Gygi, Steve P., Charest, Al
Published in Cell Rep (2019)

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

by Kazak, Lawrence, Chouchani, Edward T., Jedrychowski, Mark P., Erickson, Brian K., Shinoda, Kosaku, Cohen, Paul, Vetrivelan, Ramalingam, Lu, Gina Z., Laznik-Bogoslavski, Dina, Hasenfuss, Sebastian C., Kajimura, Shingo, Gygi, Steve P., Spiegelman, Bruce M.
Published in Cell (2015)

Tetracyclines promote survival and fitness in mitochondrial disease models

by Perry, Elizabeth A., Bennett, Christopher F., Luo, Chi, Balsa, Eduardo, Jedrychowski, Mark, O’Malley, Katherine, Latorre-Muro, Pedro, Ladley, Richard Porter, Reda, Kamar, Wright, Peter M., Gygi, Steve P., Myers, Andrew G., Puigserver, Pere
Published in Nat Metab (2021)

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

by Barrow, Joeva J., Balsa, Eduardo, Verdeguer, Francisco, Tavares, Clint D. J., Soustek, Meghan S., Hollingsworth, Louis R., Jedrychowski, Mark, Vogel, Rutger, Paulo, Joao A., Smeitink, Jan, Gygi, Steve P., Doench, John, Root, David E., Puigserver, Pere
Published in Mol Cell (2016)

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

by Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.
Published in Nature (2016)

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA

by Yamazaki, Tomohiro, Chen, Shi, Yu, Yong, Yan, Biao, Haertlein, Tyler C., Carrasco, Monica A., Tapia, Juan C., Zhai, Bo, Das, Rita, Lalancette-Hebert, Melanie, Sharma, Aarti, Chandran, Siddharthan, Sullivan, Gareth, Nishimura, Agnes Lumi, Shaw, Christopher E., Gygi, Steve P., Shneider, Neil A., Maniatis, Tom, Reed, Robin
Published 2012

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

by Jun, Hyun Jung, Appleman, Vicky A., Wu, Hua-Jun, Rose, Christopher M., Pineda, Javier J., Yeo, Alan T., Delcuze, Bethany, Lee, Charlotte, Gyuris, Aron, Zhu, Haihao, Woolfenden, Steve, Bronisz, Agnieszka, Nakano, Ichiro, Chiocca, Ennio A., Bronson, Roderick T., Ligon, Keith L., Sarkaria, Jann N., Gygi, Steve P., Michor, Franziska, Mitchison, Timothy J., Charest, Al
Published in Nat Commun (2018)

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

by Sharabi, Kfir, Lin, Hua, Tavares, Clint D. J., Dominy, John E., Camporez, Joao Paulo, Perry, Rachel J., Schilling, Roger, Rines, Amy K., Lee, Jaemin, Hickey, Marc, Bennion, Melissa, Palmer, Michelle, Nag, Partha P., Bittker, Joshua A., Perez, José, Jedrychowski, Mark P., Ozcan, Umut, Gygi, Steve P., Kamenecka, Theodore M., Shulman, Gerald I., Schreiber, Stuart L., Griffin, Patrick R., Puigserver, Pere
Published in Cell (2017)