Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

Mitochondrial diseases comprise a heterogeneous group of genetically inherited disorders that cause failures in energetic and metabolic function. Boosting residual oxidative phosphorylation (OXPHOS) activity can partially correct these failures. Herein, using a high-throughput chemical screen, we id...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Barrow, Joeva J., Balsa, Eduardo, Verdeguer, Francisco, Tavares, Clint D. J., Soustek, Meghan S., Hollingsworth, Louis R., Jedrychowski, Mark, Vogel, Rutger, Paulo, Joao A., Smeitink, Jan, Gygi, Steve P., Doench, John, Root, David E., Puigserver, Pere
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055448/
https://ncbi.nlm.nih.gov/pubmed/27666594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.023
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