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Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies associated with mitochondrial diseases. However, the pr...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7264245/ https://ncbi.nlm.nih.gov/pubmed/32483148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16423-1 |
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