Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies associated with mitochondrial diseases. However, the pr...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Balsa, Eduardo, Perry, Elizabeth A., Bennett, Christopher F., Jedrychowski, Mark, Gygi, Steven P., Doench, John G., Puigserver, Pere
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264245/
https://ncbi.nlm.nih.gov/pubmed/32483148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16423-1
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