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Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells

Mitochondrial mutations cause bioenergetic defects associated with failures to use the electron transfer chain and oxidize substrates. These defects are exacerbated under energetic stress conditions and ultimately cause cell deterioration and death. However, little is known about cellular strategies...

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Publicat a:Cell Death Dis
Autors principals: Soustek, Meghan S., Balsa, Eduardo, Barrow, Joeva J., Jedrychowski, Mark, Vogel, Rutger, Jan Smeitink, Gygi, Steve P., Puigserver, Pere
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981317/
https://ncbi.nlm.nih.gov/pubmed/29855477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0696-5
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