Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

Mitochondrial diseases comprise a heterogeneous group of genetically inherited disorders that cause failures in energetic and metabolic function. Boosting residual oxidative phosphorylation (OXPHOS) activity can partially correct these failures. Herein, using a high-throughput chemical screen, we id...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Barrow, Joeva J., Balsa, Eduardo, Verdeguer, Francisco, Tavares, Clint D. J., Soustek, Meghan S., Hollingsworth, Louis R., Jedrychowski, Mark, Vogel, Rutger, Paulo, Joao A., Smeitink, Jan, Gygi, Steve P., Doench, John, Root, David E., Puigserver, Pere
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055448/
https://ncbi.nlm.nih.gov/pubmed/27666594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.023
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