A high-content small molecule screen identifies novel inducers of definitive endoderm

von Korostylev, Alexander, Mahaddalkar, Pallavi U., Keminer, Oliver, Hadian, Kamyar, Schorpp, Kenji, Gribbon, Philip, Lickert, Heiko
Veröffentlicht in Mol Metab (2017)

Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors

von Sassetti, Elisa, Durante Cruz, Cristina, Tammela, Päivi, Winterhalter, Mathias, Augustyns, Koen, Gribbon, Philip, Windshügel, Björn
Veröffentlicht in Int J Mol Sci (2019)

The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor

von Bosma, Reggie, Witt, Gesa, Vaas, Lea A. I., Josimovic, Ivana, Gribbon, Philip, Vischer, Henry F., Gul, Sheraz, Leurs, Rob
Veröffentlicht in Front Pharmacol (2017)

Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp. MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production

von Kebede, Bethlehem, Wrigley, Stephen K., Prashar, Anjali, Rahlff, Janina, Wolf, Markus, Reinshagen, Jeanette, Gribbon, Philip, Imhoff, Johannes F., Silber, Johanna, Labes, Antje, Ellinger, Bernhard
Veröffentlicht in Mar Drugs (2017)

Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα

von Hering, Yuliya, Berthier, Alexandre, Duez, Helene, Lefebvre, Philippe, Deprez, Benoit, Gribbon, Philip, Wolf, Markus, Reinshagen, Jeanette, Halley, Francoise, Hannemann, Juliane, Böger, Rainer, Staels, Bart, Gul, Sheraz
Veröffentlicht in J Biol Methods (2018)

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

von Ellinger, Bernhard, Bojkova, Denisa, Zaliani, Andrea, Cinatl, Jindrich, Claussen, Carsten, Westhaus, Sandra, Keminer, Oliver, Reinshagen, Jeanette, Kuzikov, Maria, Wolf, Markus, Geisslinger, Gerd, Gribbon, Philip, Ciesek, Sandra
Veröffentlicht in Sci Data (2021)

A Phenotypic Screening Approach to Identify Anticancer Compounds Derived from Marine Fungi

von Ellinger, Bernhard, Silber, Johanna, Prashar, Anjali, Landskron, Johannes, Weber, Jonas, Rehermann, Sarah, Müller, Franz-Josef, Smith, Stephen, Wrigley, Stephen, Taskén, Kjetil, Gribbon, Philip, Labes, Antje, Imhoff, Johannes F.
Veröffentlicht 2014

In vitro and in silico analysis of the effects of D (2) receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

von de Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, van der Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, de Lange, Elizabeth C M
Veröffentlicht in Br J Pharmacol (2018)

An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds

von Witt, Gesa, Keminer, Oliver, Leu, Jennifer, Tandon, Rashmi, Meiser, Ina, Willing, Anne, Winschel, Ingo, Abt, Jana-Christin, Brändl, Björn, Sébastien, Isabelle, Friese, Manuel A., Müller, Franz-Josef, Neubauer, Julia C., Claussen, Carsten, Zimmermann, Heiko, Gribbon, Philip, Pless, Ole
Veröffentlicht in Cell Biol Toxicol (2020)

Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments

von Tanoli, Ziaurrehman, Aldahdooh, Jehad, Alam, Farhan, Wang, Yinyin, Seemab, Umair, Fratelli, Maddalena, Pavlis, Petr, Hajduch, Marian, Bietrix, Florence, Gribbon, Philip, Zaliani, Andrea, Hall, Matthew D., Shen, Min, Brimacombe, Kyle, Kulesskiy, Evgeny, Saarela, Jani, Wennerberg, Krister, Vähä-Koskela, Markus, Tang, Jing
Veröffentlicht in bioRxiv (2021)

A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics

von Gossen, Jonas, Albani, Simone, Hanke, Anton, Joseph, Benjamin P., Bergh, Cathrine, Kuzikov, Maria, Costanzi, Elisa, Manelfi, Candida, Storici, Paola, Gribbon, Philip, Beccari, Andrea R., Talarico, Carmine, Spyrakis, Francesca, Lindahl, Erik, Zaliani, Andrea, Carloni, Paolo, Wade, Rebecca C., Musiani, Francesco, Kokh, Daria B., Rossetti, Giulia
Veröffentlicht in ACS Pharmacol Transl Sci (2021)

Activation of caspase-6 is promoted by a mutant huntingtin fragment and blocked by an allosteric inhibitor compound

von Ehrnhoefer, Dagmar E, Skotte, Niels H, Reinshagen, Jeanette, Qiu, Xiaofan, Windshügel, Björn, Jaishankar, Priyadarshini, Ladha, Safia, Petina, Olga, Khankischpur, Mehdi, Nguyen, Yen TN, Caron, Nicholas S, Razeto, Adelia, zu Rheda, Matthias Meyer, Deng, Yu, Huynh, Khuong T, Wittig, Ilka, Gribbon, Philip, Renslo, Adam R., Geffken, Detlef, Gul, Sheraz, Hayden, Michael R
Veröffentlicht in Cell Chem Biol (2019)

ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

von Sharifi, M. Amin, Wierer, Michael, Dang, Tan An, Milic, Jelena, Moggio, Aldo, Sachs, Nadja, von Scheidt, Moritz, Hinterdobler, Julia, Müller, Philipp, Werner, Julia, Stiller, Barbara, Aherrahrou, Zouhair, Erdmann, Jeanette, Zaliani, Andrea, Graettinger, Mira, Reinshagen, Jeanette, Gul, Sheraz, Gribbon, Philip, Maegdefessel, Lars, Bernhagen, Jürgen, Sager, Hendrik B., Mann, Matthias, Schunkert, Heribert, Kessler, Thorsten
Veröffentlicht in Circ Res (2023)

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

von Kuzikov, Maria, Costanzi, Elisa, Reinshagen, Jeanette, Esposito, Francesca, Vangeel, Laura, Wolf, Markus, Ellinger, Bernhard, Claussen, Carsten, Geisslinger, Gerd, Corona, Angela, Iaconis, Daniela, Talarico, Carmine, Manelfi, Candida, Cannalire, Rolando, Rossetti, Giulia, Gossen, Jonas, Albani, Simone, Musiani, Francesco, Herzog, Katja, Ye, Yang, Giabbai, Barbara, Demitri, Nicola, Jochmans, Dirk, Jonghe, Steven De, Rymenants, Jasper, Summa, Vincenzo, Tramontano, Enzo, Beccari, Andrea R., Leyssen, Pieter, Storici, Paola, Neyts, Johan, Gribbon, Philip, Zaliani, Andrea
Veröffentlicht in ACS Pharmacol Transl Sci (2021)

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

von Linciano, Pasquale, Dawson, Alice, Pöhner, Ina, Costa, David M., Sá, Monica S., Cordeiro-da-Silva, Anabela, Luciani, Rosaria, Gul, Sheraz, Witt, Gesa, Ellinger, Bernhard, Kuzikov, Maria, Gribbon, Philip, Reinshagen, Jeanette, Wolf, Markus, Behrens, Birte, Hannaert, Véronique, Michels, Paul A. M., Nerini, Erika, Pozzi, Cecilia, di Pisa, Flavio, Landi, Giacomo, Santarem, Nuno, Ferrari, Stefania, Saxena, Puneet, Lazzari, Sandra, Cannazza, Giuseppe, Freitas-Junior, Lucio H., Moraes, Carolina B., Pascoalino, Bruno S., Alcântara, Laura M., Bertolacini, Claudia P., Fontana, Vanessa, Wittig, Ulrike, Müller, Wolfgang, Wade, Rebecca C., Hunter, William N., Mangani, Stefano, Costantino, Luca, Costi, Maria P.
Veröffentlicht in ACS Omega (2017)

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

von Brennecke, Philip, Rasina, Dace, Aubi, Oscar, Herzog, Katja, Landskron, Johannes, Cautain, Bastien, Vicente, Francisca, Quintana, Jordi, Mestres, Jordi, Stechmann, Bahne, Ellinger, Bernhard, Brea, Jose, Kolanowski, Jacek L., Pilarski, Radosław, Orzaez, Mar, Pineda-Lucena, Antonio, Laraia, Luca, Nami, Faranak, Zielenkiewicz, Piotr, Paruch, Kamil, Hansen, Espen, von Kries, Jens P., Neuenschwander, Martin, Specker, Edgar, Bartunek, Petr, Simova, Sarka, Leśnikowski, Zbigniew, Krauss, Stefan, Lehtiö, Lari, Bilitewski, Ursula, Brönstrup, Mark, Taskén, Kjetil, Jirgensons, Aigars, Lickert, Heiko, Clausen, Mads H., Andersen, Jeanette H., Vicent, Maria J., Genilloud, Olga, Martinez, Aurora, Nazaré, Marc, Fecke, Wolfgang, Gribbon, Philip
Veröffentlicht in SLAS Discov (2019)

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

von Günther, Sebastian, Reinke, Patrick Y. A., Fernández-García, Yaiza, Lieske, Julia, Lane, Thomas J., Ginn, Helen M., Koua, Faisal H. M., Ehrt, Christiane, Ewert, Wiebke, Oberthuer, Dominik, Yefanov, Oleksandr, Meier, Susanne, Lorenzen, Kristina, Krichel, Boris, Kopicki, Janine-Denise, Gelisio, Luca, Brehm, Wolfgang, Dunkel, Ilona, Seychell, Brandon, Gieseler, Henry, Norton-Baker, Brenna, Escudero-Pérez, Beatriz, Domaracky, Martin, Saouane, Sofiane, Tolstikova, Alexandra, White, Thomas A., Hänle, Anna, Groessler, Michael, Fleckenstein, Holger, Trost, Fabian, Galchenkova, Marina, Gevorkov, Yaroslav, Li, Chufeng, Awel, Salah, Peck, Ariana, Barthelmess, Miriam, Schlünzen, Frank, Lourdu Xavier, P., Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Falke, Sven, Srinivasan, Vasundara, França, Bruno Alves, Schwinzer, Martin, Brognaro, Hévila, Rogers, Cromarte, Melo, Diogo, Zaitseva-Doyle, Joanna J., Knoska, Juraj, Peña-Murillo, Gisel E., Mashhour, Aida Rahmani, Hennicke, Vincent, Fischer, Pontus, Hakanpää, Johanna, Meyer, Jan, Gribbon, Philip, Ellinger, Bernhard, Kuzikov, Maria, Wolf, Markus, Beccari, Andrea R., Bourenkov, Gleb, von Stetten, David, Pompidor, Guillaume, Bento, Isabel, Panneerselvam, Saravanan, Karpics, Ivars, Schneider, Thomas R., Garcia-Alai, Maria Marta, Niebling, Stephan, Günther, Christian, Schmidt, Christina, Schubert, Robin, Han, Huijong, Boger, Juliane, Monteiro, Diana C. F., Zhang, Linlin, Sun, Xinyuanyuan, Pletzer-Zelgert, Jonathan, Wollenhaupt, Jan, Feiler, Christian G., Weiss, Manfred S., Schulz, Eike-Christian, Mehrabi, Pedram, Karničar, Katarina, Usenik, Aleksandra, Loboda, Jure, Tidow, Henning, Chari, Ashwin, Hilgenfeld, Rolf, Uetrecht, Charlotte, Cox, Russell, Zaliani, Andrea, Beck, Tobias, Rarey, Matthias, Günther, Stephan, Turk, Dusan, Hinrichs, Winfried, Chapman, Henry N., Pearson, Arwen R., Betzel, Christian, Meents, Alke
Veröffentlicht in Science (2021)