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Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
[Image: see text] Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of Leishmania major PTR1 for activity against Trypanosoma brucei (Tb). We solved crystal structures...
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| Vydáno v: | ACS Omega |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical Society
2017
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5623949/ https://ncbi.nlm.nih.gov/pubmed/28983525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00473 |
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