In vitro and in silico analysis of the effects of D (2) receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

BACKGROUND AND PURPOSE: Target binding kinetics influence the time course of the drug effect (pharmacodynamics) both (i) directly, by affecting the time course of target occupancy, driven by the pharmacokinetics of the drug, competition with endogenous ligands and target turnover, and (ii) indirectl...

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Publicat a:Br J Pharmacol
Autors principals: de Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, van der Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, de Lange, Elizabeth C M
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177617/
https://ncbi.nlm.nih.gov/pubmed/30051456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14456
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