Modeling of prolactin response following dopamine D(2) receptor antagonists in rats: can it be translated to clinical dosing?

Prolactin release is a side effect of antipsychotic therapy with dopamine antagonists, observed in rats as well as humans. We examined whether two semimechanistic models could describe prolactin response in rats and subsequently be translated to predict pituitary dopamine D(2) receptor occupancy and...

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Publicado en:Pharmacol Res Perspect
Autores principales: Taneja, Amit, Vermeulen, An, Huntjens, Dymphy R. H., Danhof, Meindert, De Lange, Elizabeth C. M., Proost, Johannes H.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723698/
https://ncbi.nlm.nih.gov/pubmed/29226628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.364
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