Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

Drug–target binding kinetics (as determined by association and dissociation rate constants, k(on) and k(off)) can be an important determinant of the kinetics of drug action. However, the effect compartment model is used most frequently instead of a target binding model to describe hysteresis. Here w...

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Detalhes bibliográficos
Publicado no:J Pharmacokinet Pharmacodyn
Main Authors: de Witte, Wilhelmus E. A., Rottschäfer, Vivi, Danhof, Meindert, van der Graaf, Piet H., Peletier, Lambertus A., de Lange, Elizabeth C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061075/
https://ncbi.nlm.nih.gov/pubmed/29777407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-018-9593-x
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