Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

Drug–target binding kinetics (as determined by association and dissociation rate constants, k(on) and k(off)) can be an important determinant of the kinetics of drug action. However, the effect compartment model is used most frequently instead of a target binding model to describe hysteresis. Here w...

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Bibliographic Details
Published in:J Pharmacokinet Pharmacodyn
Main Authors: de Witte, Wilhelmus E. A., Rottschäfer, Vivi, Danhof, Meindert, van der Graaf, Piet H., Peletier, Lambertus A., de Lange, Elizabeth C. M.
Format: Artigo
Language:Inglês
Published: Springer US 2018
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061075/
https://ncbi.nlm.nih.gov/pubmed/29777407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-018-9593-x
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