Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG

BACKGROUND AND PURPOSE: The aim was to investigate the influence of biophase distribution including P-glycoprotein (Pgp) function on the pharmacokinetic-pharmacodynamic correlations of morphine's actions in rat brain. EXPERIMENTAL APPROACH: Male rats received a 10-min infusion of morphine as 4 ...

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Detalhes bibliográficos
Main Authors: Groenendaal, D, Freijer, J, de Mik, D, Bouw, M R, Danhof, M, de Lange, E C M
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013992/
https://ncbi.nlm.nih.gov/pubmed/17471181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707258
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