Pharmacokinetic-pharmacodynamic modelling of S(−)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint

BACKGROUND AND PURPOSE: For development of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models, continuous recording of drug effects is essential. We therefore explored the use of isoprenaline in the continuous measurement of the cardiovascular effects of antagonists of β-adrenoceptors (β...

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Main Authors:	van Steeg, T J, Freijer, J, Danhof, M, de Lange, E C M
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2007
Fag:	Research Papers
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2013984/ https://ncbi.nlm.nih.gov/pubmed/17420778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707234
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Pharmacokinetic-pharmacodynamic modelling of S(−)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint

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