Pharmacokinetic–pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex

BACKGROUND AND PURPOSE: The pharmacokinetic–pharmacodynamic (PK–PD) correlation of fluvoxamine 5-HT transporter (SERT) occupancy was determined in rat frontal cortex ex vivo. EXPERIMENTAL APPROACH: Rats (n=47) with permanent arterial and venous cannulas received a 30 min intravenous infusion of fluv...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Geldof, M, Freijer, J I, van Beijsterveldt, L, Langlois, X, Danhof, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483389/
https://ncbi.nlm.nih.gov/pubmed/18493251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.179
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados