Pharmacokinetic–pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex

BACKGROUND AND PURPOSE: The pharmacokinetic–pharmacodynamic (PK–PD) correlation of fluvoxamine 5-HT transporter (SERT) occupancy was determined in rat frontal cortex ex vivo. EXPERIMENTAL APPROACH: Rats (n=47) with permanent arterial and venous cannulas received a 30 min intravenous infusion of fluv...

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Bibliografiset tiedot
Päätekijät: Geldof, M, Freijer, J I, van Beijsterveldt, L, Langlois, X, Danhof, M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2008
Aiheet:
Research Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483389/
https://ncbi.nlm.nih.gov/pubmed/18493251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.179
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