Structures of adenosine kinase from Trypanosoma brucei brucei

Por Timm, Jennifer, González-Pacanowska, Dolores, Wilson, Keith S.
Publicado em 2013

Characterization of uracil-DNA glycosylase activity from Trypanosoma cruzi and its stimulation by AP endonuclease

Por Fárez-Vidal, M. Esther, Gallego, Cláribel, Ruiz-Pérez, Luis Miguel, González-Pacanowska, Dolores
Publicado em 2001

2-Alkylaminoethyl-1,1-Bisphosphonic Acids Are Potent Inhibitors of the Enzymatic Activity of Trypanosoma cruzi Squalene Synthase

Por Rodrígues-Poveda, Carlos A., González-Pacanowska, Dolores, Szajnman, Sergio H., Rodríguez, Juan B.
Publicado em 2012

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity

Por Cordon-Obras, Carlos, Cano, Jorge, González-Pacanowska, Dolores, Benito, Agustin, Navarro, Miguel, Bart, Jean-Mathieu
Publicado em 2013

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Por Aripirala, Srinivas, Gonzalez-Pacanowska, Dolores, Oldfield, Eric, Kaiser, Marcel, Amzel, L. Mario, Gabelli, Sandra B.
Publicado em 2014

Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family

Por Castillo-Acosta, Víctor M., Ruiz-Pérez, Luis M., Yang, Wei, González-Pacanowska, Dolores, Vidal, Antonio E.
Publicado em 2009

Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major

Por Timm, Jennifer, Bosch-Navarrete, Cristina, Recio, Eliseo, Nettleship, Joanne E., Rada, Heather, González-Pacanowska, Dolores, Wilson, Keith S.
Publicado no PLoS Negl Trop Dis (2015)

Farnesyl Diphosphate Synthase Is a Cytosolic Enzyme in Leishmania major Promastigotes and Its Overexpression Confers Resistance to Risedronate

Por Ortiz-Gómez, Aurora, Jiménez, Carmen, Estévez, Antonio M., Carrero-Lérida, Juana, Ruiz-Pérez, Luis M., González-Pacanowska, Dolores
Publicado em 2006

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major

Por Hidalgo-Zarco, Fernando, Camacho, Ana G., Bernier-Villamor, Victor, Nord, Johan, Ruiz-Pérez, Luis Miguel, González-Pacanowska, Dolores
Publicado em 2001

Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity

Por Castillo-Acosta, Víctor M., Ruiz-Pérez, Luis M., Van Damme, Els J. M., Balzarini, Jan, González-Pacanowska, Dolores
Publicado no PLoS Negl Trop Dis (2015)

The Crystal Structure of the Leishmania major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, dUMP, and Deoxyuridine

Por Hemsworth, Glyn R., Moroz, Olga V., Fogg, Mark J., Scott, Benjamin, Bosch-Navarrete, Cristina, González-Pacanowska, Dolores, Wilson, Keith S.
Publicado em 2011

Kinetic Characterization of Squalene Synthase from Trypanosoma cruzi: Selective Inhibition by Quinuclidine Derivatives

Por Sealey-Cardona, Marco, Cammerer, Simon, Jones, Simon, Ruiz-Pérez, Luis M., Brun, Reto, Gilbert, Ian H., Urbina, Julio A., González-Pacanowska, Dolores
Publicado em 2007

Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase()

Por Hampton, Shahienaz E., Schipani, Alessandro, Bosch-Navarrete, Cristina, Recio, Eliseo, Kaiser, Marcel, Kahnberg, Pia, González-Pacanowska, Dolores, Johansson, Nils Gunnar, Gilbert, Ian H.
Publicado em 2013

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

Por Castillo-Acosta, Víctor M., Ruiz-Pérez, Luis M., Etxebarria, Juan, Reichardt, Niels C., Navarro, Miguel, Igarashi, Yasuhiro, Liekens, Sandra, Balzarini, Jan, González-Pacanowska, Dolores
Publicado no PLoS Pathog (2016)

Mitochondrial Localization of the Mevalonate Pathway Enzyme 3-Hydroxy-3-methyl-glutaryl-CoA Reductase in the Trypanosomatidae

Por Peña-Diaz, Javier, Montalvetti, Andrea, Flores, Carmen-Lisset, Constán, Aurora, Hurtado-Guerrero, Ramon, De Souza, Wanderley, Gancedo, Carlos, Ruiz-Perez, Luis M., Gonzalez-Pacanowska, Dolores
Publicado em 2004

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

Por Cui, Huaqing, Carrero-Lérida, Juana, Silva, Ana P. G., Whittingham, Jean L., Brannigan, James A., Ruiz-Pérez, Luis M., Read, Kevin D., Wilson, Keith S., González-Pacanowska, Dolores, Gilbert, Ian H.
Publicado em 2012

Quinuclidine Derivatives as Potential Antiparasitics

Por Cammerer, Simon B., Jimenez, Carmen, Jones, Simon, Gros, Ludovic, Lorente, Silvia Orenes, Rodrigues, Carlos, Rodrigues, Juliany C. F., Caldera, Aura, Ruiz Perez, Luis Miguel, da Souza, Wanderley, Kaiser, Marcel, Brun, Reto, Urbina, Julio A., Gonzalez Pacanowska, Dolores, Gilbert, Ian H.
Publicado em 2007

SQ109, a New Drug Lead for Chagas Disease

Por Veiga-Santos, Phercyles, Li, Kai, Lameira, Lilianne, de Carvalho, Tecia Maria Ulisses, Huang, Guozhong, Galizzi, Melina, Shang, Na, Li, Qian, Gonzalez-Pacanowska, Dolores, Hernandez-Rodriguez, Vanessa, Benaim, Gustavo, Guo, Rey-Ting, Urbina, Julio A., Docampo, Roberto, de Souza, Wanderley, Oldfield, Eric
Publicado no Antimicrob Agents Chemother (2015)

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

Por Pérez-Moreno, Guiomar, Cantizani, Juan, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Martín, Jesús, el Aouad, Noureddine, Pérez-Victoria, Ignacio, Tormo, José Rubén, González-Menendez, Víctor, González, Ignacio, de Pedro, Nuria, Reyes, Fernando, Genilloud, Olga, Vicente, Francisca, González-Pacanowska, Dolores
Publicado no PLoS One (2016)

Squalene Synthase As a Target for Chagas Disease Therapeutics

Por Shang, Na, Li, Qian, Ko, Tzu-Ping, Chan, Hsiu-Chien, Li, Jikun, Zheng, Yingying, Huang, Chun-Hsiang, Ren, Feifei, Chen, Chun-Chi, Zhu, Zhen, Galizzi, Melina, Li, Zhu-Hong, Rodrigues-Poveda, Carlos A., Gonzalez-Pacanowska, Dolores, Veiga-Santos, Phercyles, de Carvalho, Tecia Maria Ulisses, de Souza, Wanderley, Urbina, Julio A., Wang, Andrew H.-J., Docampo, Roberto, Li, Kai, Liu, Yi-Liang, Oldfield, Eric, Guo, Rey-Ting
Publicado em 2014