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Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family

DNA single-strand breaks containing 3′-blocking groups are generated from attack of the sugar backbone by reactive oxygen species or after base excision by DNA glycosylase/apurinic/apyrimidinic (AP) lyases. In human cells, APE1 excises sugar fragments that block the 3′-ends thus facilitating DNA rep...

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Main Authors: Castillo-Acosta, Víctor M., Ruiz-Pérez, Luis M., Yang, Wei, González-Pacanowska, Dolores, Vidal, Antonio E.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665217/
https://ncbi.nlm.nih.gov/pubmed/19181704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp021
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