Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

[Image: see text] Plasmodium falciparum thymidylate kinase (PfTMPK) is a key enzyme in pyrimidine nucleotide biosynthesis. 3-Trifluoromethyl-4-chloro-phenyl-urea-α-thymidine has been reported as an inhibitor of Mycobacterium tuberculosis TMPK (MtTMPK). Starting from this point, we designed, synthesi...

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Main Authors: Cui, Huaqing, Carrero-Lérida, Juana, Silva, Ana P. G., Whittingham, Jean L., Brannigan, James A., Ruiz-Pérez, Luis M., Read, Kevin D., Wilson, Keith S., González-Pacanowska, Dolores, Gilbert, Ian H.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2012
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530961/
https://ncbi.nlm.nih.gov/pubmed/23240776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301328h
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