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Synthesis and Evaluation of Febrifugine Analogues as Potential Antimalarial Agents
Febrifugine is an alkaloid isolated from Dichroa febrifuga Lour as the active component against Plasmodium falciparum. Strong liver toxicity has precluded febrifugine as a potential clinical drug. In this study novel febrifugine analogues were designed and synthesized. Lower toxicity was achieved by...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2072810/ https://ncbi.nlm.nih.gov/pubmed/16434194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.01.009 |
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