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Synthesis and Evaluation of Febrifugine Analogues as Potential Antimalarial Agents

Febrifugine is an alkaloid isolated from Dichroa febrifuga Lour as the active component against Plasmodium falciparum. Strong liver toxicity has precluded febrifugine as a potential clinical drug. In this study novel febrifugine analogues were designed and synthesized. Lower toxicity was achieved by...

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Autors principals: Zhu, Shuren, Meng, Li, Zhang, Quan, Wei, Lai
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072810/
https://ncbi.nlm.nih.gov/pubmed/16434194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.01.009
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