Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase()

Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationally restrained amide derivatives as inhibitors PfdUTPase, including both acyclic and cyclic examples....

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Detalhes bibliográficos
Main Authors: Hampton, Shahienaz E., Schipani, Alessandro, Bosch-Navarrete, Cristina, Recio, Eliseo, Kaiser, Marcel, Kahnberg, Pia, González-Pacanowska, Dolores, Johansson, Nils Gunnar, Gilbert, Ian H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776224/
https://ncbi.nlm.nih.gov/pubmed/23916149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.07.004
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