Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity

BACKGROUND: Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-malarials is required. Deoxyuridine 5′-triphosphate nucleot...

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Bibliographic Details
Published in:Malar J
Main Authors: Pérez-Moreno, Guiomar, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Johansson, Nils Gunnar, Müller, Sylke, Baragaña, Beatriz, Hampton, Shahienaz Emma, Gilbert, Ian Hugh, Kaiser, Marcel, Sarkar, Sandipan, Pandurangan, Thiyagamurthy, Kumar, Vijeesh, González-Pacanowska, Dolores
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889535/
https://ncbi.nlm.nih.gov/pubmed/31796083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-019-3025-2
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