Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity

BACKGROUND: Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-malarials is required. Deoxyuridine 5′-triphosphate nucleot...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Malar J
Autori principali: Pérez-Moreno, Guiomar, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Johansson, Nils Gunnar, Müller, Sylke, Baragaña, Beatriz, Hampton, Shahienaz Emma, Gilbert, Ian Hugh, Kaiser, Marcel, Sarkar, Sandipan, Pandurangan, Thiyagamurthy, Kumar, Vijeesh, González-Pacanowska, Dolores
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889535/
https://ncbi.nlm.nih.gov/pubmed/31796083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-019-3025-2
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