Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase()

Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationally restrained amide derivatives as inhibitors PfdUTPase, including both acyclic and cyclic examples....

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Hauptverfasser: Hampton, Shahienaz E., Schipani, Alessandro, Bosch-Navarrete, Cristina, Recio, Eliseo, Kaiser, Marcel, Kahnberg, Pia, González-Pacanowska, Dolores, Johansson, Nils Gunnar, Gilbert, Ian H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776224/
https://ncbi.nlm.nih.gov/pubmed/23916149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.07.004
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