Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

Por Nocentini, Alessio, Bonardi, Alessandro, Gratteri, Paola, Cerra, Bruno, Gioiello, Antimo, Supuran, Claudiu T.
Publicado no J Enzyme Inhib Med Chem (2018)

Enantioselective HPLC Analysis to Assist the Chemical Exploration of Chiral Imidazolines

Por Cerra, Bruno, Macchiarulo, Antonio, Carotti, Andrea, Camaioni, Emidio, Varfaj, Ina, Sardella, Roccaldo, Gioiello, Antimo
Publicado no Molecules (2020)

Synthesis and Quantitative Structure-Property Relationships of Side Chain-Modified Hyodeoxycholic Acid Derivatives

Por Sabbatini, Paola, Filipponi, Paolo, Sardella, Roccaldo, Natalini, Benedetto, Nuti, Roberto, Macchiarulo, Antonio, Pellicciari, Roberto, Gioiello, Antimo
Publicado no Molecules (2013)

Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists

Por Cerra, Bruno, Carotti, Andrea, Passeri, Daniela, Sardella, Roccaldo, Moroni, Giada, Di Michele, Alessandro, Macchiarulo, Antonio, Pellicciari, Roberto, Gioiello, Antimo
Publicado no ACS Med Chem Lett (2018)

Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool

Por Passeri, Daniela, Carotti, Andrea, Pittol, Jose M. Ramos, Ciaccioli, Gianmario, Pellicciari, Roberto, van Mil, Saskia W. C., Gioiello, Antimo
Publicado no Medchemcomm (2019)

Bile Acid Recognition by NAPE-PLD

Por Margheritis, Eleonora, Castellani, Beatrice, Magotti, Paola, Peruzzi, Sara, Romeo, Elisa, Natali, Francesca, Mostarda, Serena, Gioiello, Antimo, Piomelli, Daniele, Garau, Gianpiero
Publicado no ACS Chem Biol (2016)

Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators

Por Pellicciari, Roberto, Gioiello, Antimo, Sabbatini, Paola, Venturoni, Francesco, Nuti, Roberto, Colliva, Carolina, Rizzo, Giovanni, Adorini, Luciano, Pruzanski, Mark, Roda, Aldo, Macchiarulo, Antonio
Publicado em 2012

TGR5-mediated bile acid sensing controls glucose homeostasis

Por Thomas, Charles, Gioiello, Antimo, Noriega, Lilia, Strehle, Axelle, Oury, Julien, Rizzo, Giovanni, Macchiarulo, Antonio, Yamamoto, Hiroyasu, Mataki, Chikage, Pruzanski, Mark, Pellicciari, Roberto, Auwerx, Johan, Schoonjans, Kristina
Publicado em 2009

Probing the Binding Site of Bile Acids in TGR5

Por Macchiarulo, Antonio, Gioiello, Antimo, Thomas, Charles, Pols, Thijs W. H., Nuti, Roberto, Ferrari, Cristina, Giacchè, Nicola, De Franco, Francesca, Pruzanski, Mark, Auwerx, Johan, Schoonjans, Kristina, Pellicciari, Roberto
Publicado em 2013

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

Por Pols, Thijs W.H., Nomura, Mitsunori, Harach, Taoufiq, Sasso, Giuseppe Lo, Oosterveer, Maaike H., Thomas, Charles, Rizzo, Giovanni, Gioiello, Antimo, Adorini, Luciano, Pellicciari, Roberto, Auwerx, Johan, Schoonjans, Kristina
Publicado em 2011

The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression

Por Bijsmans, Ingrid T. G. W., Guercini, Chiara, Ramos Pittol, José M., Omta, Wienand, Milona, Alexandra, Lelieveld, Daphne, Egan, David A., Pellicciari, Roberto, Gioiello, Antimo, van Mil, Saskia W. C.
Publicado no Sci Rep (2015)

Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor

Por Russo, Simonetta, Incerti, Matteo, Tognolini, Massimiliano, Castelli, Riccardo, Pala, Daniele, Hassan-Mohamed, Iftiin, Giorgio, Carmine, De Franco, Francesca, Gioiello, Antimo, Vicini, Paola, Barocelli, Elisabetta, Rivara, Silvia, Mor, Marco, Lodola, Alessio
Publicado no Molecules (2013)

Weak Microbial Metabolites: a Treasure Trove for Using Biomimicry to Discover and Optimize Drugs

Por Dvorak, Zdenek, Klapholz, Max, Burris, Thomas P., Willing, Benjamin P., Gioiello, Antimo, Pellicciari, Roberto, Galli, Francesco, March, John, O’Keefe, Stephen J., Sartor, R. Balfour, Kim, Chang H., Levy, Maayan, Mani, Sridhar
Publicado no Mol Pharmacol (2020)

Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain

Por Marinelli, Rita, Torquato, Pierangelo, Bartolini, Desirée, Mas-Bargues, Cristina, Bellezza, Guido, Gioiello, Antimo, Borras, Consuelo, De Luca, Antonella, Fallarino, Francesca, Sebastiani, Bartolomeo, Mani, Sridhar, Sidoni, Angelo, Viña, Jose, Leri, Manuela, Bucciantini, Monica, Nardiello, Pamela, Casamenti, Fiorella, Galli, Francesco
Publicado no J Biol Chem (2020)