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Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool
Guggulsterone is a promiscuous ligand for endocrine and metabolic lipid receptors traditionally used to treat a number of diseases including diabesity, hyperlipidemia, atherosclerosis, and osteoarthritis. Although relatively weak, its activity at the farnesoid X receptor (FXR) is particularly intrig...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6786047/ https://ncbi.nlm.nih.gov/pubmed/31673308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00264b |
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