The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression

The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Bijsmans, Ingrid T. G. W., Guercini, Chiara, Ramos Pittol, José M., Omta, Wienand, Milona, Alexandra, Lelieveld, Daphne, Egan, David A., Pellicciari, Roberto, Gioiello, Antimo, van Mil, Saskia W. C.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572934/
https://ncbi.nlm.nih.gov/pubmed/26369990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14086
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items