The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression

The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Bijsmans, Ingrid T. G. W., Guercini, Chiara, Ramos Pittol, José M., Omta, Wienand, Milona, Alexandra, Lelieveld, Daphne, Egan, David A., Pellicciari, Roberto, Gioiello, Antimo, van Mil, Saskia W. C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572934/
https://ncbi.nlm.nih.gov/pubmed/26369990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14086
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