Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor

The Eph–ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to inhibit EphA2 activation in prostate cancer cells. H...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Russo, Simonetta, Incerti, Matteo, Tognolini, Massimiliano, Castelli, Riccardo, Pala, Daniele, Hassan-Mohamed, Iftiin, Giorgio, Carmine, De Franco, Francesca, Gioiello, Antimo, Vicini, Paola, Barocelli, Elisabetta, Rivara, Silvia, Mor, Marco, Lodola, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270184/
https://ncbi.nlm.nih.gov/pubmed/24152675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules181013043
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