Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor

The Eph receptor–ephrin system is an emerging target for the development of novel antiangiogenetic agents. We recently identified lithocholic acid (LCA) as a small molecule able to block EphA2-dependent signals in cancer cells, suggesting that its (5β)-cholan-24-oic acid scaffold can be used as a te...

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Autori principali: Incerti, Matteo, Tognolini, Massimiliano, Russo, Simonetta, Pala, Daniele, Giorgio, Carmine, Hassan-Mohamed, Iftiin, Noberini, Roberta, Pasquale, Elena B., Vicini, Paola, Piersanti, Silvia, Rivara, Silvia, Barocelli, Elisabetta, Mor, Marco, Lodola, Alessio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953198/
https://ncbi.nlm.nih.gov/pubmed/23489211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301890k
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