Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor

The Eph receptor–ephrin system is an emerging target for the development of novel antiangiogenetic agents. We recently identified lithocholic acid (LCA) as a small molecule able to block EphA2-dependent signals in cancer cells, suggesting that its (5β)-cholan-24-oic acid scaffold can be used as a te...

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Bibliografiske detaljer
Main Authors: Incerti, Matteo, Tognolini, Massimiliano, Russo, Simonetta, Pala, Daniele, Giorgio, Carmine, Hassan-Mohamed, Iftiin, Noberini, Roberta, Pasquale, Elena B., Vicini, Paola, Piersanti, Silvia, Rivara, Silvia, Barocelli, Elisabetta, Mor, Marco, Lodola, Alessio
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953198/
https://ncbi.nlm.nih.gov/pubmed/23489211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301890k
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