Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor

The Eph receptor–ephrin system is an emerging target for the development of novel antiangiogenetic agents. We recently identified lithocholic acid (LCA) as a small molecule able to block EphA2-dependent signals in cancer cells, suggesting that its (5β)-cholan-24-oic acid scaffold can be used as a te...

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Bibliografiska uppgifter
Huvudupphovsmän: Incerti, Matteo, Tognolini, Massimiliano, Russo, Simonetta, Pala, Daniele, Giorgio, Carmine, Hassan-Mohamed, Iftiin, Noberini, Roberta, Pasquale, Elena B., Vicini, Paola, Piersanti, Silvia, Rivara, Silvia, Barocelli, Elisabetta, Mor, Marco, Lodola, Alessio
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953198/
https://ncbi.nlm.nih.gov/pubmed/23489211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301890k
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