TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

The G-protein coupled receptor TGR5 has been identified as an important component of the bile acid signaling network and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here we demonstrate that TGR5 is expressed in macrophages, and that its activation by...

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Hauptverfasser: Pols, Thijs W.H., Nomura, Mitsunori, Harach, Taoufiq, Sasso, Giuseppe Lo, Oosterveer, Maaike H., Thomas, Charles, Rizzo, Giovanni, Gioiello, Antimo, Adorini, Luciano, Pellicciari, Roberto, Auwerx, Johan, Schoonjans, Kristina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627293/
https://ncbi.nlm.nih.gov/pubmed/22152303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.11.006
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