TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

The G-protein coupled receptor TGR5 has been identified as an important component of the bile acid signaling network and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here we demonstrate that TGR5 is expressed in macrophages, and that its activation by...

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Main Authors: Pols, Thijs W.H., Nomura, Mitsunori, Harach, Taoufiq, Sasso, Giuseppe Lo, Oosterveer, Maaike H., Thomas, Charles, Rizzo, Giovanni, Gioiello, Antimo, Adorini, Luciano, Pellicciari, Roberto, Auwerx, Johan, Schoonjans, Kristina
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627293/
https://ncbi.nlm.nih.gov/pubmed/22152303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.11.006
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