TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

Anionic exchange resins are bona fide cholesterol-lowering agents with glycemia lowering actions in diabetic patients. Potentiation of intestinal GLP-1 secretion has been proposed to contribute to the glycemia lowering effect of these non-systemic drugs. Here, we show that resin exposure enhances GL...

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Main Authors: Harach, Taoufiq, Pols, Thijs W. H., Nomura, Mitsunori, Maida, Adriano, Watanabe, Mitsuhiro, Auwerx, Johan, Schoonjans, Kristina
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362799/
https://ncbi.nlm.nih.gov/pubmed/22666533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00430
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